maintrac
maintrac® is a blood test that allows us to detect cells which have left the tumor and entered the bloodstream.
Some of these so-called circulating (epithelial) tumor cells (CETCs / CTCs) may be responsible for metastases (metastatic spread) occurring, and thus responsible for further progression of the disease.
Using the maintrac® cell count, the extent to which a treatment is proving successful can be monitored. For this assessment, the number of circulating cells is determined before therapy start, and is compared with the number of cells over the course of therapy. The resulting progression of results gives an indication of whether cells are being destroyed by the cancer therapy, i.e. whether the patient is responding to the treatment. Should this not be the case, there is the possibility of testing other substances directly on the circulating tumor cells.
Some substances are only effective in the treatment of cancer if the tumor exhibits certain properties. maintrac® can determine whether these therapy-relevant properties are exhibited in the tumor cells.
Only 15 ml of EDTA blood needs to be taken from the patient by the treating physician, or in the specialized medical laboratory Dr. Pachmann, which is then subsequently analyzed in the diagnostic laboratory.
maintrac® helps each individual patient to find a unique, personalized and effective therapy, allowing for the success of the therapy to be monitored.
The advantages of maintrac® are:
maintrac® can be employed in the case of almost all solid tumors.
Treatment success can be monitored both before therapy start and over the course of therapy with maintrac® diagnostics. maintrac® may also find application in metastatic situations, during hormone and maintenance therapies and watch-and-wait approaches (e.g. in cases of prostate cancer or DCIS-type breast cancer).
The significance of maintrac® diagnostics has already been proven in 15 studies involving over 940 patients. These publications, as well as many others on the topic of circulating tumor cells can be found on the Publications page.
Due to the high sensitivity of the techniques involved, CETCs / CTCs can be detected shortly after a primary tumor has been diagnosed, and as such a therapy decision can be made in good time. This early detection relies mainly on the fact that maintrac® is highly-sensitive because the cells from the blood sample are analyzed in real-time, contrasting with other methods where cells tend to be fixed, isolated or enriched. This allows a quantitative determination of CETCs / CTCs even in the early stages of disease, and not only once a metastatic stage has been reached.
